Endothelial NLRP3 inflammasome regulation in atherosclerosis

CONCLUSIONS: Our findings highlight the existence of a glycolysis-dependent NADH/CtBP/FOXP1-transrepression pathway that regulates endothelial NLRP3 inflammasome activation in atherogenesis. This pathway represents a potential target for selective PFKFB3 inhibitors or strategies aimed at disrupting CtBP1 oligomerization to modulate atherosclerosis.PMID:38626254 | DOI:10.1093/cvr/cvae071

Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Shuai Guo Litao Wang Kaixiang Cao Ziling Li Mingchuan Song Shuqi Huang Zou Li Cailing Wang Peiling Chen Yong Wang Xiaoyan Dai Xianglin Chen Xiaodong Fu Du Feng Jun He Yuqing Huo Yiming Xu Source Type: research