Diffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features

CONCLUSIONS: GNH defines an aggressive subtype of mainly biphasic DPMs in younger patients with recurrent alterations in SETDB1 and TP53. The enrichment in biphasic histology and TILs, together with our preliminary ICB response data and anecdotal clinical trial data, suggests that further evaluation of immunotherapy may be warranted in this subset.PMID:38630790 | DOI:10.1158/1078-0432.CCR-24-0085

Source: Clinical Cancer Research - April 17, 2024 Category: Cancer & Oncology Authors: Soo-Ryum Yang Gowtham Jayakumaran Jamal Benhamida Christopher A Febres Aldana Rachel Fanaroff Jason Chang Erika Gedvilaite Liliana B Villafania Jennifer L Sauter Michael Offin Marjorie G Zauderer Marc Ladanyi Source Type: research