153 Lattice radiotherapy (LRT): Safely Dose Escalating Palliative Radiotherapy

Lattice radiotherapy (LRT) is a novel technique of delivering inhomogeneous doses of radiation to voluminous tumours. LRT is relevant in the treatment of large tumour volumes where standard palliative radiotherapy doses are unlikely to achieve meaningful tumour and symptom control, and dose escalation to the entire PTV is likely to carry a significant risk of increased toxicity. For lattice radiotherapy, a 3D-array of focal hot spots called vertices are created within the tumour PTV. The vertices are postulated to produce more efficient immunogenic cell death whilst the remainder of the PTV is covered by a standard palliative dose.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Radiotherapy Source Type: research