Clinical impact of transient lymphopenia

In this study, 240 patients (142 men; 98 female; mean age 75.1  ± 15.1) were enrolled. Patients were divided into two groups according to the lymphocytes count at hospital admission, namely “Group A” with lymphopenia and “Group B” with values in the normal range. Moreover, the patients in group A were distinguished in relation to the regression or persistence of the lymphopenia assessed at the time of hospital discharge (Group A1: persistence; Group A2: normalization). Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; and none differences were observed regarding ge nder. Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; no differences were observed regarding gender. All subsets of the lymphocytes (CD4+, CD8+, NK) were equally reduced. Persistent lymphopenia was found in 19% of patients. Lymphopenia should be valued at the time of hospital admission as a factor influencing the prognosis, the management and the treatment of these patients.
Source: Clinical and Experimental Medicine - Category: Research Source Type: research