GSE254993 The pulmonary inflammatory microenvironment at the time of exposure governs innate control of SARS-CoV-2 replication

Contributors : Paul J Baker ; Andrea C Bohrer ; Eduardo P Amaral ; Ehydel Castro ; Maryonne Snow-Smith ; Flor Torres-Ju árez ; Artur T Queiroz ; Eduardo F Rocha ; Sydnee T Gould ; Cassandra M Jordan ; Jaspal S Khillan ; Kyoungin Cho ; Reed F Johnson ; Daniel L Barber ; Bruno B Andrade ; Kerry L Hilligan ; Katrin D Mayer-BarberSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSARS-CoV-2 (SCV2) infection leads to diverse clinical outcomes ranging from asymptomatic to fatal disease. Co-morbidities, age and host genetics together with immune status affect disease severity. However, the range of innate inflammatory pathways critical for limiting early viral replication and whether the inflammatory history and milieu of the lung microenvironment at the time of exposure impacts early control of SCV2 infection remain largely unexplored. Here, we investigated the roel of prior TLR stimualtion on early viral rpelciation in the lungs of K18 mice
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research