Promiscuous G-protein activation by the calcium-sensing receptor

Nature, Published online: 17 April 2024; doi:10.1038/s41586-024-07331-1Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity.

Source: Nature AOP - April 17, 2024 Category: Research Authors: Hao Zuo Jinseo Park Aurel Frangaj Jianxiang Ye Guanqi Lu Jamie J. Manning Wesley B. Asher Zhengyuan Lu Guo-bin Hu Liguo Wang Joshua Mendez Edward Eng Zhening Zhang Xin Lin Robert Grassucci Wayne A. Hendrickson Oliver B. Clarke Jonathan A. Javitch Arthur D Source Type: research