Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity

Mini Rev Med Chem. 2024 Apr 16. doi: 10.2174/0113895575302197240408121537. Online ahead of print.ABSTRACTOne of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as linkers in numerous synthetic compounds with a variety of activities, according to the findings of several investigations. As a result, the current review will give readers a thorough understanding of the key ideas put forth by different researchers regarding the anticonvulsant properties of Schiff bases. It will serve as a valuable information source for those planning to synthesize new anticonvulsant molecules that contain Schiff bases as pharmacophores or biologically active moieties.PMID:38629363 | DOI:10.2174/0113895575302197240408121537

Source: Mini Reviews in Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Rakesh Sahu Kamal Shah Source Type: research