Low and high-order topological disruption of functional networks in multiple system atrophy with freezing of gait: A resting-state study

CONCLUSION: This study identified a disrupted topology of functional interactions at both low and high levels with extensive alterations in topological properties in MSA patients with FOG, especially those associated with damage to the FPN. These findings offer new insights into the dysfunctional mechanisms of complex networks and suggest potential neuroimaging biomarkers for FOG in patients with MSA.PMID:38615913 | DOI:10.1016/j.nbd.2024.106504

Source: Neurobiology of Disease - April 14, 2024 Category: Neurology Authors: Guoguang Fan Mengwan Zhao Huize Pang Xiaolu Li Shuting Bu Juzhou Wang Yu Liu Yueluan Jiang Source Type: research