Anxiety in Alzheimer's disease rats is independent of memory and impacted by genotype, age, sex, and exercise

DISCUSSION: Concluding that while factors such as age, sex, AD genotype, and training status can impact anxiety levels in the TgF344-AD model, anxiety level did not impact memory performance.HIGHLIGHTS: Increased anxiety-like behavior in TgF344-AD rats does not correlate with declines in memory performance. Predictors of higher anxiety-like behaviors in the TgF344-AD rat include age, Alzheimer's disease (AD) genotype, and sex with female AD animals experiencing greater anxiety compared to female wild-type or male AD. Exercise training leads to decreased anxiety-like behaviors in the TgF344-AD rat.PMID:38624069 | DOI:10.1002/alz.13813
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research