Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8, Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations and their Association with Disease Susceptibility and Mortality in COVID-19 Patients

CONCLUSION: The findings of this study provide important insights into the COVID-19 disease and susceptibility risk. The polymorphisms in TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896 and CXCR2 +785 C>T (rs2230054) are associated with the risk of susceptibility to COVID-19 and with mortality in COVID-19 patients. Further studies with larger sample sizes are necessary to confirm our findings.PMID:38544825 | PMC:PMC10964085 | DOI:10.2174/0113892029272497240103052359

Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Badr A Alsayed Rashid Mir Mohammad M Mir Tarig M S Alnour Shereen Fawzy Mesaik M Ahmed Dnyanesh Amle Source Type: research