Synthesis and biological evaluation of EGFR binding peptides for near-infrared photoimmunotherapy

In this study, we developed a novel PIT drug using a peptide as the target-directed molecule. Epidermal growth factor receptor (EGFR) was selected as the target, and monovalent and bivalent EGFR-binding peptides were synthesized. The bivalent peptide showed sufficient binding to EGFR-positive cells, and a bivalent peptide-IR700 conjugate with a long linker induced morphological changes in EGFR-positive cells. Additionally, the drug significantly reduced cell viability in vitro in an NIR light-dose- and drug-concentration-dependent manner. These results indicate the feasibility of NIR-PIT in treating cancer using peptide-based drugs.PMID:38614014 | DOI:10.1016/j.bmc.2024.117717
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Source Type: research