Algorithm Training and Testing for a Nonendoscopic Barrett ’s Esophagus Detection Test in Prospective Multicenter Cohorts

Endoscopic Barrett ’s esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Nonendoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort.

Source: Clinical Gastroenterology and Hepatology - March 19, 2024 Category: Gastroenterology Authors: Prasad G. Iyer, Seth W. Slettedahl, Douglas W. Mahoney, Maria Giakoumopoulos, Marilyn C. Olson, Martin Krockenberger, William R. Taylor, Patrick Foote, Calise Berger, Cadman Leggett, Tsung-Teh Wu, Eduardo Antpack, Gary W. Falk, Gregory G. Ginsberg, Julian Source Type: research