Remi-fent 1-A pragmatic randomised controlled study to evaluate the feasibility of using remifentanil or fentanyl as sedation adjuncts in mechanically ventilated patients

CONCLUSIONS: We demonstrated the feasibility of enrolling patients for a pRCT comparing remifentanil and fentanyl as sedation adjuncts in mechanically ventilated patients. We failed to attain the study-opioid compliance target, likely because of patients with complex sedative/analgesic requirements. Secondary outcomes suggest that remifentanil may reduce mechanical ventilation duration and decrease the incidence of complications. An adequately powered multicentric phase 2 study is required to evaluate these results.PMID:38234321 | PMC:PMC10790007 | DOI:10.1016/j.ccrj.2023.10.012

Source: Critical Care and Resuscitation - January 18, 2024 Category: Intensive Care Authors: Arvind Rajamani Ashwin Subramaniam Brian Lung Kristy Masters Rebecca Gresham Christina Whitehead Julie Lowrey Ian Seppelt Hemant Kumar Jayashree Kumar Anwar Hassan Sam Orde Pranav Arun Bharadwaj Hemamalini Arvind Stephen Huang SPARTAN Collaborative Source Type: research