GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the cannabinoid CB < sub > 1 < /sub > receptor and the consequences on G protein signalling

This study supports the hypothesis that arrestin-biased ligands for CB1 must engage GRK5/6 rather than GRK2/3, and G protein-biased ligands must have inherently low efficacy.PMID:38604257 | DOI:10.1016/j.bcp.2024.116190
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research