Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

CONCLUSIONS: Chitin, as a general CLP blocker, reduces CLP production, enhances anti-tumor immunity as well as ICB responses, supporting its potential clinical relevance in immunosuppressed TNBC patients.PMID:38605414 | DOI:10.1186/s13058-024-01815-8

Source: Cell Research - April 11, 2024 Category: Cytology Authors: Robbe Salembier Caro De Haes Julie Bellemans Kristel Demeyere Wim Van Den Broeck Niek N Sanders Steven Van Laere Traci R Lyons Evelyne Meyer Jonas Steenbrugge Source Type: research