Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging

CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.PMID:38569839 | DOI:10.2463/mrms.mp.2024-0011

Source: Magnetic Resonance in Medical Sciences - April 3, 2024 Category: Radiology Authors: Shinji Naganawa Rintaro Ito Mariko Kawamura Toshiaki Taoka Tadao Yoshida Michihiko Sone Source Type: research