Insights into the structure-activity relationship of the anticancer compound ZJ-101: A role played by the amide moiety

Bioorg Med Chem Lett. 2024 Apr 8:129741. doi: 10.1016/j.bmcl.2024.129741. Online ahead of print.ABSTRACTZJ-101, a structurally simplified analog of marine natural product superstolide A, was previously designed and synthesized in our laboratory. In the present study four new analogs of ZJ-101 were designed and synthesized to investigate the structure-activity relationship of the acetamide moiety of the molecule. The biological evaluation showed that the amide moiety is important for the molecule's anticancer activity. Replacing the amide with other unctional groups such as a sulfonamide group, a carbamate group, and a urea group resulted in the decrease in anticancer activity.PMID:38599296 | DOI:10.1016/j.bmcl.2024.129741
Source: Bioorganic and Medicinal Chemistry Letters - Category: Chemistry Authors: Source Type: research