Nasal oxidative stress mediating the effects of colder temperature exposure on pediatric asthma symptoms

CONCLUSION: These results suggest a plausible pathway that colder temperature exposure worsens pediatric asthma symptoms partly via inducing nasal oxidative stress.IMPACT: The role of oxidative stress in linking colder temperature exposure and worsened asthma symptoms is still poorly understood. Lower temperature exposure in a colder season was associated with higher nasal and systemic oxidative stress in children with asthma. Nasal MDA, a biomarker of nasal oxidative stress, mediated the associations between colder temperature exposures and pediatric asthma symptoms. The results firstly suggest a plausible pathway that colder temperature exposure worsens pediatric asthma symptoms partly via inducing oxidative stress in the nasal cavity.PMID:38605092 | DOI:10.1038/s41390-024-03196-2

Source: Pediatric Research - April 11, 2024 Category: Pediatrics Authors: Linchen He Christina Norris Kimberly Palaguachi-Lopez Karoline Barkjohn Zhen Li Feng Li Yinping Zhang Marilyn Black Michael H Bergin Junfeng Jim Zhang Source Type: research