Euphorbia Bicolor Phytochemicals Reduce Oxidative Stress, Inflammatory Mediators, and Pain Signaling in a Rat Model of Burn Pain

Pain associated with burn injury has been linked to oxidative stress, inflammation, and nociceptor sensitization and can lead to chronic pain. Burn pain is challenging to manage with non-steroidal anti-inflammatory drugs, opioids, and gabapentinoids; all of which are linked to undesirable side effects. Novel strategies that mitigate burn pain are needed. Euphorbia bicolor, a native Texas plant, contains phytochemicals that could serve as a novel analgesic(s). We hypothesized that E. bicolor phytochemicals reduce pain and inflammatory key markers present in the blood, sensory ganglia, and spinal cord that contribute to burn pain behaviors.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research