Adipose-Derived miR-133a-3p And Its Role in Mechanical Sensitivity in Chronic Primary Pain Conditions

To identify pain-relevant miRNAs downstream of beta adrenergic receptor ( βAR) activation and determine their functional effects in chronic primary pain conditions (CPPCs). Rats received peripheral delivery of the β2- and β3AR antagonists ICI-118,511 (1.5mg/kg/day) and SR59230A (1.67 mg/kg/day) alongside systemic delivery of the catechol-o-methlytransferase inhibitor O R486 (15mg/kg/day) or vehicle over 14 days (N=20). RNA sequencing shows that OR486 treatment decreased levels of miR-133a in circulation, and this downregulation was prevented by βAR antagonism.

Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Nathaniel P. Hernandez, Jiegen Chen, Xin Zhang, Yaomin Wang, Xianglong Gao, Brittney P. Ciszek, Matt Kanke, Mohamad Karaky, Marguerita E. Klein, Praveen Sethupathy, Luda Diatchenko, Andrea G. Nackley Source Type: research