Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12  Isolated from Aquilaria sinensis

Chem Biodivers. 2024 Apr 11:e202400567. doi: 10.1002/cbdv.202400567. Online ahead of print.ABSTRACTFive new cytochalasins, diaporchalasins A-E (1-5), together with 14 known congeners (6-19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high-resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C-21 displayed cytotoxicity toward K562, BEL-7402, SGC-7901, A549, and HeLa cell lines with IC50 values ranging from 4.4 to 47.4 μM.PMID:38602253 | DOI:10.1002/cbdv.202400567

Source: Chemistry and Biodiversity - April 11, 2024 Category: Biochemistry Authors: Li Yang Qi Wang Qing-Yun Ma Qing-Yi Xie Cui-Juan Gai You-Gen Wu Hao-Fu Dai Zhao Youxing Source Type: research