SOX17: escape route from immune destruction in early CRC

Trends Mol Med. 2024 Apr 9:S1471-4914(24)00089-3. doi: 10.1016/j.molmed.2024.04.001. Online ahead of print.ABSTRACTIn a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5- (LGR5-) tumor cells, which suppress interferon gamma (IFNγ) signaling and promote immune escape.PMID:38594095 | DOI:10.1016/j.molmed.2024.04.001
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Source Type: research