IgE to cyclophilins in pollen-allergic children: Epidemiologic, clinical, and diagnostic relevance of a neglected panallergen

Some allergens are restricted to one or a few allergenic species, while others, called panallergens, can induce IgE-mediated cross-reactivity between homologous allergens from phylogenetically distant species.1 Members of the panallergen families exert functions that are so relevant for life that their tertiary structure is conserved through evolution, thus explaining their broad immunologic cross-reactivity.2 Panallergens are often not the major cause of the symptoms, but they can be associated with multiple sensitization,3 comorbidities such as pollen-food allergy syndrome4 or asthma,5 and interfere with the diagnostic identification of the culprit allergen,6 thus hampering precise prescription of allergen immunotherapy (AIT).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research