IgE to cyclophilins in pollen-allergic children: Epidemiologic, clinical, and diagnostic relevance of a neglected panallergen
Some allergens are restricted to one or a few allergenic species, while others, called panallergens, can induce IgE-mediated cross-reactivity between homologous allergens from phylogenetically distant species.1 Members of the panallergen families exert functions that are so relevant for life that their tertiary structure is conserved through evolution, thus explaining their broad immunologic cross-reactivity.2 Panallergens are often not the major cause of the symptoms, but they can be associated with multiple sensitization,3 comorbidities such as pollen-food allergy syndrome4 or asthma,5 and interfere with the diagnostic identification of the culprit allergen,6 thus hampering precise prescription of allergen immunotherapy (AIT).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Paolo Maria Matricardi, Ekaterina Potapova, Valentina Panetta, Jonas Lidholm, Lars Mattsson, Enrico Scala, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia del Source Type: research
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