ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells

CONCLUSION.: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is associated with suppression of cell proliferation and tumor growth.PMID:38563293 | DOI:10.2478/enr-2024-0006

Source: Endocrine Regulations - April 2, 2024 Category: Endocrinology Authors: Daria A Krasnytska Olena O Khita Yuliia M Viletska Dmytro O Minchenko Oleh V Halkin Olha V Rudnytska Sofiia L Hoian Oleksandr H Minchenko Source Type: research