Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis

CONCLUSION: These findings suggest a multiphasic model of aortic wall failure in which primary lesions of intimomedial tears either heal if the media is sufficiently resilient or progress as dissection or rupture by medial delamination and tear completion, respectively. Moreover, mural incorporation of thrombus and cellular responses to injury, two historically important concepts in atheroma pathogenesis, contribute to vessel wall repair with adequate conduit function but even together are not sufficient to induce atherosclerosis.FUNDING: R01-HL146723, R01-HL168473, and Yale Department of Surgery.PMID:38592807 | DOI:10.1172/jci.insight.172437
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research