Mitophagy mediated by HIF-1 α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury

In conclusion, the HIF-1α/FUNDC1 signaling pathway mediates H/R-promoted renal tubular cell mitophagy, whereas inhibition of this signaling pathway protects cells from mitophagy, thus aggravating apoptosis, and ROS production. Accordingly, roxadustat may protect against RIRI-related AKI.PMID:38584135 | PMC:PMC11000611 | DOI:10.1080/0886022X.2024.2332492

Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wenjun Zhang Chao Guo Yi Li Hao Wang Huabing Wang Yingying Wang Tingting Wu Huinan Wang Gang Cheng Jiangwei Man Siyu Chen Shengjun Fu Li Yang Source Type: research