Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis
Drug-induced hypersensitivity syndrome (DiHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS), is a severe cutaneous adverse reaction (SCAR) characterized by an exanthem, fever, and hematologic and visceral organ involvement. Anticonvulsants, antibiotics, and allopurinol are the most common triggers. The pathogenesis involves a complex interplay between drugs, viruses, and the immune system primarily mediated by T-cells. DiHS/DRESS typically presents with a morbilliform eruption 2-6 weeks after drug exposure, and is associated with significant morbidity, mortality, and risk of relapse.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Brian M. Wei, Lindy P. Fox, Benjamin H. Kaffenberger, Abraham M. Korman, Robert G. Micheletti, Arash Mostaghimi, Megan H. Noe, Misha Rosenbach, Kanade Shinkai, Jason H. Kwah, Elizabeth J. Phillips, Jean L. Bolognia, William Damsky, Caroline A. Nelson Tags: Continuing medical education Source Type: research
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