Necroptosis blockade prevents lung injury in severe influenza

Nature, Published online: 10 April 2024; doi:10.1038/s41586-024-07265-8A newly developed RIPK3 inhibitor blocks necroptosis of lung cells, reduces lung inflammation and prevents mortality in a mouse model of influenza A virus infection.

Source: Nature AOP - April 10, 2024 Category: Research Authors: Avishekh Gautam David F. Boyd Sameer Nikhar Ting Zhang Ioannis Siokas Lee-Ann Van de Velde Jessica Gaevert Victoria Meliopoulos Bikash Thapa Diego A. Rodriguez Kathy Q. Cai Chaoran Yin Daniel Schnepf Julius Beer Carly DeAntoneo Riley M. Williams Maria Shu Source Type: research