Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00402G, PaperYuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari Post-synthetic conversion of the trifluoromethyl group to a heteroaryl group at the C5 position of the pyrimidine base in the oligonucleotide was achieved. Specifically, oligonucleotides containing 5-trifluoromethylpyrimidine bases were treated... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research