3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3+2]-cycloaddition with arynes. Synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00391H, CommunicationAlexander A. Lukoyanov, Svetlana Aksenova, Andrey Tabolin, Alexey Yu. Sukhorukov The reaction of 3-halo-5,6-dihydro-4H-1,2-oxazine N-oxides with arynes was studied. Arynes were generated from o-silylaryl triflates and underwent consecutive [3+2]-cycloaddition/[4+2]-cycloreversion with N-oxides leading to substituted 3-vinyl-benzisoxazoles in high yields. In the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research