Copper-Catalyzed Asymmetric Friedel-Crafts Hydroxyalkylation of Pyrazole-4,5-diones with  5-Aminoisoxazoles

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00322E, CommunicationSiyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang An asymmetric Friedel-Crafts hydroxyalkylation reaction of 5-aminoisoxazoles with pyrazole-4,5-diones was developed under the catalysis of 5% chiral copper complexes. This reaction exhibits a functional group tolerance and excellent enantioselectivity. Moreover,... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - April 9, 2024 Category: Molecular Biology Authors: Siyu Gao Source Type: research