Molecules, Vol. 29, Pages 1701: Iodine-Catalyzed Cascade Annulation of 4-Hydroxycoumarins with Aurones: Access to Spirocyclic Benzofuran & ndash;Furocoumarins

Molecules, Vol. 29, Pages 1701: Iodine-Catalyzed Cascade Annulation of 4-Hydroxycoumarins with Aurones: Access to Spirocyclic Benzofuran–Furocoumarins Molecules doi: 10.3390/molecules29081701 Authors: Xuequan Wang Changhui Yang Dan Yue Mingde Xu Suyue Duan Xianfu Shen An attractive approach for the preparation of spirocyclic benzofuran–furocoumarins has been developed through iodine-catalyzed cascade annulation of 4-hydroxycoumarins with aurones. The reaction involves Michael addition, iodination, and intramolecular nucleophilic substitution in a one-step process, and offers an efficient method for easy access to a series of valuable spirocyclic benzofuran–furocoumarins in good yields (up to 99%) with excellent stereoselectivity. Moreover, this unprecedented protocol provides several advantages, including readily available materials, an environmentally benign catalyst, a broad substrate scope, and a simple procedure.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research