Influenza C virus susceptibility to antivirals with different mechanisms of action

Antimicrob Agents Chemother. 2024 Apr 8:e0172723. doi: 10.1128/aac.01727-23. Online ahead of print.ABSTRACTAntiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC50 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.PMID:38587392 | DOI:10.1128/aac.01727-23

Source: Antimicrobial Agents and Chemotherapy - April 8, 2024 Category: Microbiology Authors: Anton Chesnokov Andrei A Ivashchenko Yoko Matsuzaki Emi Takashita Vasiliy P Mishin Alexandre V Ivachtchenko Larisa V Gubareva Source Type: research