The cytotoxic, genotoxic and mitotoxic effects of Atractylis gummifera extract in vitro

Conclusion: This work highlights cellular and mitochondrial adverse effects of Atractylis gummifera extracts. A purified fractionthat likely corresponds to ATR derivatives induces MPTP opening leading to swelling of mitochondria and its dysfunction. Alliumcepa test provides the evidence for A. gummifera genotoxicity and cytotoxicity.Keywords: Atractylis gummifera; Allium cepa test; mitochondrial permeability transition pore; genotoxicity; cytotoxicity; chromosomalaberration; mitotic index.
Source: African Health Sciences - Category: African Health Authors: Source Type: research