Molecules, Vol. 29, Pages 1687: Enhancement of Astaxanthin Bioaccessibility by Encapsulation in Liposomes: An In Vitro Study

Molecules, Vol. 29, Pages 1687: Enhancement of Astaxanthin Bioaccessibility by Encapsulation in Liposomes: An In Vitro Study Molecules doi: 10.3390/molecules29081687 Authors: Li Pan Haojie Meng Jiaqi Li Zongjie Liu Dongsheng Zhang Zhengyang Liu Qian Zhao Fei Xu Astaxanthin was encapsulated in liposomes by a thin layer dispersion and ultrasound method using soybean phospholipid. The digestion properties of liposomes for encapsulating astaxanthin were investigated in light of particle size, size distribution, zeta potential, and microstructure during in vitro digestion as a function of time. These results exhibited that the average particle size increased gradually with liposomal vesicles retained round shapes and a fairly uniform distribution after passage through the simulated gastric fluid digestion. The result revealed that astaxanthin-loaded liposomes were stable in low pH conditions. It was also found that the mixed micelles formed in a simulated intestinal fluid. The zeta potential of astaxanthin-loaded liposomes had a decrease in negativity after digestion. In comparison with free astaxanthin, there was an appreciable increase in the bioaccessibility of astaxanthin after encapsulation in liposomes. This enhancement can be attributed to more soluble astaxanthin in the mixed micelles for astaxanthin-loaded liposomes. It indicated that the barrier of the liposomal bilayer could inhibit astaxanthin fading and leaking after encapsulation in liposomes. T...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research