Role of chitosan in intestinal integrity: TLR4 and IFNAR signaling in the induction of E-cadherin and CD103 in mice

In this study we evaluated the ability of orally administered Q to stimulate E-cadherin and CD103 expression in vitro and in vivo. Our findings show that Q promoted epithelial cell migration, accelerated wound healing and increased E-cadherin expression in IEC-18 cells and isolated intestinal epithelial cells (IECs) after Q feeding. The upregulation of E-cadherin was dependent on TLR4 and IFNAR signaling, triggering CD103 expression in lymphocytes. Q reinforced the E-cadherin-αEβ7 axis, crucial for intestinal barrier integrity and contributed to the localization of lymphocytes on the epithelium.PMID:38582475 | DOI:10.1016/j.ijbiomac.2024.131334

Source: International Journal of Biological Macromolecules - April 6, 2024 Category: Biochemistry Authors: Luciana Moine Maria Magdalena Canali Silvina R Salinas Ismael D Bianco Carina Porporatto Silvia G Correa Source Type: research