A General Approach to Patients Presenting With Locally Advanced or Distant Metastatic Disease

Cancer J. 2024 Mar-Apr 01;30(2):48-53. doi: 10.1097/PPO.0000000000000704.ABSTRACTThe widespread adoption of immune checkpoint inhibitors and small molecule inhibitors of the MAP kinase pathway has transformed the management of locally advanced and metastatic melanoma. Here, we provide a broad overview on the use of these agents in the first-line setting, incorporating a review of the clinical literature as well as the practice patterns of our respective melanoma groups. Throughout, we highlight areas of uncertainty that provide opportunities for future clinical investigation and additional improvement in outcomes for patients with melanoma.PMID:38527257 | DOI:10.1097/PPO.0000000000000704
Source: Cancer Journal - Category: Cancer & Oncology Authors: Source Type: research