FTY720 Suppresses Pathogenic Retinal M üller Cell Activation and Chronic Progression by Inhibiting the mTOR/NF-κB Signaling Pathway and Regulating Autophagy

CONCLUSIONS: This study suggests that in an HG-induced rMC-1 cell model, FTY720 significantly inhibited the production of inflammatory cytokines by inhibiting mTOR/NF-κB signaling and regulating autophagy. These findings were associated with a decrease in rMC-1 cell injury, suggesting that FTY720 or related compounds may be valuable modulators of HG-induced retinal injury.PMID:38577836 | DOI:10.1080/02713683.2024.2337301

Source: Current Eye Research - April 5, 2024 Category: Opthalmology Authors: Yanting Yang Yan Liu Huan Tang Qing Zhou Huanhuan Li E Song Source Type: research