Building and integrating brain-wide maps of nervous system function in invertebrates

Curr Opin Neurobiol. 2024 Apr 2;86:102868. doi: 10.1016/j.conb.2024.102868. Online ahead of print.ABSTRACTThe selection and execution of context-appropriate behaviors is controlled by the integrated action of neural circuits throughout the brain. However, how activity is coordinated across brain regions, and how nervous system structure enables these functional interactions, remain open questions. Recent technical advances have made it feasible to build brain-wide maps of nervous system structure and function, such as brain activity maps, connectomes, and cell atlases. Here, we review recent progress in this area, focusing on C. elegans and D. melanogaster, as recent work has produced global maps of these nervous systems. We also describe neural circuit motifs elucidated in studies of specific networks, which highlight the complexities that must be captured to build accurate models of whole-brain function.PMID:38569231 | DOI:10.1016/j.conb.2024.102868

Source: Current Opinion in Neurobiology - April 3, 2024 Category: Neurology Authors: Talya S Kramer Steven W Flavell Source Type: research