Transcriptional and functional profiling identifies inflammation and endothelial to mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of Endothelial Colony Forming Cells

CONCLUSION: We observed a range of different RNA expression patterns between ECFC clones mostly associated with inflammation and clear differences in WPB count and structure. We developed a qPCR panel which can be used for the characterization of ECFC clones which is essential for the correct analysis of pathogenic mechanisms in vascular disorders.PMID:38574861 | DOI:10.1016/j.jtha.2024.03.018

Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sebastiaan N J Laan Suzan de Boer Richard J Dirven Iris van Moort Thomas B Kuipers Hailiang Mei Ruben Bierings Jeroen Eikenboom SYMPHONY consortium Source Type: research