Genetic haute couture to block HIV-1 at front doors

Cell Stem Cell. 2024 Apr 4;31(4):433-434. doi: 10.1016/j.stem.2024.03.009.ABSTRACTThe chemokine receptors CCR5 and CXCR4 are "front doors" for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).PMID:38579679 | DOI:10.1016/j.stem.2024.03.009
Source: Cell Stem Cell - Category: Stem Cells Authors: Source Type: research