Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-based Nanoparticles

Protein Pept Lett. 2024 Mar 20. doi: 10.2174/0109298665292469240228064739. Online ahead of print.ABSTRACTOral drug delivery is a prevalent and cost-effective method due to its advantages, such as increased drug absorption surface area and improved patient compliance. However, delivering proteins and peptides orally remains a challenge due to their vulnerability to degradation by digestive enzymes, stomach acids, and limited intestinal membrane permeability, resulting in poor bioavailability. The use of nanotechnology has emerged as a promising solution to enhance the bioavailability of these vital therapeutic agents. Polymeric NPs, made from natural or synthetic polymers, are commonly used. Natural polysaccharides, such as alginate, chitosan, dextran, starch, pectin, etc., have gained preference due to their biodegradability, biocompatibility, and versatility in encapsulating various drug types. Their hydrophobic-hydrophilic properties can be tailored to suit different drug molecules.PMID:38509673 | DOI:10.2174/0109298665292469240228064739
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research