This Month in The Journal

Although the detrimental effects of smoking on human health are well documented, our understanding of these effects at a molecular level remains incomplete. In recent years, many studies have identified associations between smoking and changes in DNA methylation, an epigenetic mark that modulates gene expression. Most of these analyses have utilized the most widely available biological sample: blood. In this issue, Li et  al. leverage data from the Genotype-Tissue Expression (GTEx) project to explore how smoking alters DNA methylation and gene expression across a range of tissues.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors' Corner Source Type: research