Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

Nyame et  al. reveal a pathological role for the Batten disease storage metabolites glycerophosphodiesters (GPDs) in the lysosome. GPDs bind and inhibit key lysosomal phospholipases, leading to accumulation of lysophospholipids, intermediates in phospholipid degradation known for their toxicity. Additionall y, they comprehensively characterize lysosomal phospholipid catabolism, a pathway crucial in several biological processes.

Source: Molecular Cell - March 5, 2024 Category: Cytology Authors: Kwamina Nyame, Andy Hims, Aya Aburous, Nouf N. Laqtom, Wentao Dong, Uche N. Medoh, Julia C. Heiby, Jian Xiong, Alessandro Ori, Monther Abu-Remaileh Tags: Article Source Type: research