Chromatin Organization in Myelodysplastic Syndrome

Myelodysplastic syndrome (MDS) is a heterogenous group of pre-leukemic myeloid malignancies involving ineffective hematopoiesis, morphological bone marrow abnormalities, and increased risk of transformation to acute myeloid leukemia (AML) [1, 2]. At current, morphological examinations of bone marrow cells and peripheral blood counts serve as the primary diagnostic and surveillance tools for MDS patients. While classically observed cytogenetic abnormalities can be pathognomonic in establishing the clonal nature of the disease, mutational abnormalities only play a supportive role in the diagnosis and management of MDS [3].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research