Dehydrative Alkynylation of 3-Hydroxyisoindolinones with Terminal Alkynes for the Synthesis of 3-Alkynylated 3,3-Disubstituted Isoindolinones

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00190G, PaperLong Chen, Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni A brand-new procedure for synthesis of 3-alkynylated 3,3-disubstituted isoindolinones has been disclosed via a HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes. Aryl, alkenyl and alkyl terminal alkynes... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research