Using hemoglobin vesicles to treat operative hemorrhagic shock after pneu- monectomy in dog models: an experimental study

In this study, we aimed to investigate HbV function during hemorrhagic shock in lung resection and analyze the details of oxygen delivery. Left pneumonectomy was performed in dogs under mechanical ventilation, followed by rapid exsanguination of approximately 30% of the total circulating blood volume, which led to shock, reducing the mean arterial pressure (MAP) by approximately 60% of baseline. Subsequently, either 5% human serum albumin (HSA) or HbVs suspended in 5% HSA were infused for resuscitation. The MAP only recovered to 75% of baseline after HSA administration, but fully recovered (100%) after HbV administration, with significant differences between the groups (P < 0.005). Oxygen delivery was restored in the HbV group and was significantly higher than that in the HSA group (P < 0.0001). The infusion of HbVs dispersed in a 5% HSA solution compensated for the rapid loss of approximately 30% of the total circulating blood volume in a dog pneumonectomy model, even with impaired lung function. Thus, HbVs can be used for resuscitation from hemorrhagic shock during thoracic surgery.PMID:38556266 | DOI:10.2220/biomedres.45.91

Source: Biomed Res - March 31, 2024 Category: Research Authors: Kei Nakano Mitsutomo Kohno Hiroto Onozawa Ryo Hashimoto Kana Oiwa Ryota Masuda Masatoshi Yamaguchi Tai Hato Masazumi Watanabe Hirohisa Horinouchi Hiromi Sakai Koichi Kobayashi Masayuki Iwazaki Source Type: research