SIRT1 coordinates transcriptional regulation of neural activity and modulates depression-like behaviors in the nucleus accumbens

Major depression and anxiety disorder are significant causes of disability and socio-economic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social defeat stress (CSDS) to induce depression- and anxiety-like behaviors. CSDS induces physiological and behavioral changes that recapitulate depression-like symptomatology and alters gene expression programs in the nucleus accumbens, yet cell type-specific changes in this critical structure remain largely unknown.

Source: Biological Psychiatry - April 2, 2024 Category: Psychiatry Authors: Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J. Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G. Park, Shenfeng Qiu, Deveroux Ferguson Tags: Archival Report Source Type: research