BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension

CONCLUSIONS: These results suggest a pivotal role of BRCC3 in sustaining pulmonary vascular homeostasis by maintaining the integrity of the BMP signaling (ie, the ALK2-Smad1/5-PPARγ axis) while suppressing TGF-β signaling in PASMCs. Such rebalance of BMP/TGF-β pathways is translationally important for PAH alleviation.PMID:38557054 | DOI:10.1161/CIRCULATIONAHA.123.066430

Source: Circulation - April 1, 2024 Category: Cardiology Authors: Hui Shen Ya Gao Dedong Ge Meng Tan Qing Yin Tong-You Wade Wei Fangzhou He Tzong-Yi Lee Zhongyan Li Yuqin Chen Qifeng Yang Zhangyu Liu Xinxin Li Zixuan Chen Yi Yang Zhengang Zhang Patricia A Thistlethwaite Jian Wang Atul Malhotra Jason X-J Yuan John Y-J Sh Source Type: research