Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation

CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214

Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research